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osm  (Santa Cruz Biotechnology)


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    Structured Review

    Santa Cruz Biotechnology osm
    Osm, supplied by Santa Cruz Biotechnology, used in various techniques. Bioz Stars score: 93/100, based on 34 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/osm/OSM+Antibody/pm41961341-103-11-12
    Average 93 stars, based on 34 article reviews
    osm - by Bioz Stars, 2026-11
    93/100 stars

    Images

    Related Articles

    Immunofluorescence:

    Article Title: Targeting the Microglia-Astrocyte OSM-OSMR Axis Restores Blood-Brain Barrier Integrity After Experimental Cerebral Ischemia-Reperfusion in Mice.
    Article Snippet: Blood–brain barrier (BBB) disruption is a major contributor to brain injury following ischemic stroke.. However, current endothelial-targeted strategies for BBB protection have shown limited clinical efficacy.. Glial cells are essential for maintaining BBB integrity, but the mechanisms underlying glial-mediated BBB dysfunction after ischemic stroke remain poorly defined.

    Cell-Signaling:

    Article Title: Targeting the Microglia-Astrocyte OSM-OSMR Axis Restores Blood-Brain Barrier Integrity After Experimental Cerebral Ischemia-Reperfusion in Mice.
    Article Snippet: Blood–brain barrier (BBB) disruption is a major contributor to brain injury following ischemic stroke.. However, current endothelial-targeted strategies for BBB protection have shown limited clinical efficacy.. Glial cells are essential for maintaining BBB integrity, but the mechanisms underlying glial-mediated BBB dysfunction after ischemic stroke remain poorly defined.

    Article Title: CCN1 Induces Oncostatin M Production in Osteoblasts via Integrin-Dependent Signal Pathways
    Article Snippet: .. Rabbit polyclonal antibody specific to phosphate p-PI3K was obtained from Cell Signaling Technology (Danvers, MA); rabbit polyclonal antibodies specific to αvβ3, p-FAK, FAK, c-Src, PI3K, p-p65, p65, β-actin, and mouse polyclonal antibodies specific to p-c-Src and OSM from Santa Cruz Biotechnology (Santa Cruz, CA). .. Human recombinant CCN1 was obtained from PeproTech (Rocky Hill, NJ), FAK inhibitor (FAKi) and c-Src inhibitor (PP2), PI3K inhibitors (Wortmannin and Ly294002), NF-κB inhibitors pyrrolidine dithiocarbamate (PDTC) and L-1-tosylamido-2-phenylenylethyl chloromethyl ketone (TPCK) from Sigma-Aldrich (St. Louis, MO).

    Article Title: Toll-Like receptor 3-mediated interferon-β production is suppressed by oncostatin m and a broader epithelial-mesenchymal transition program
    Article Snippet: Upon completion of the transfer, membranes were blocked in 1X PBS (#BP399; Fisher Bioreagents) with 0.1% Tween (#BP337-500; Fisher Bioreagents) (1X PBST) and 5% bovine serum albumin (BSA) (#BP1600; Fisher Bioreagents). .. Primary antibodies used include: OSM (#sc-390–253; Santa Cruz Biotechnology), phosphorylated STAT3 Y705 (#9145; Cell Signaling Technology), STAT3 (#9139; Cell Signaling Technology), Pan-actin (#MCA-5J11; Encore Biotechnology Inc.), phosphorylated STAT1 Y701 (#9167; Cell Signaling Technology), STAT1 (#14994; Cell Signaling Technology), phosphorylated STAT2 Y690 (#88410; Cell Signaling Technology), STAT2 (#72604; Cell Signaling Technology), IRF9 (#76684; Cell Signaling Technology), MX1 (#37849; Cell Signaling Technology), GP130 (#86384; Cell Signaling Technology), TLR3 (#6961; Cell Signaling Technology), OSMR (#10,982–1-AP; Proteintech), TGF-β (#3711; Cell Signaling Technology), Snail (#3879; Cell Signaling Technology), Zeb1 (#70512; Cell Signaling Technology), phosphorylated SMAD2 S465/S467 (#18338; Cell Signaling Technology), SMAD2 (#5339; Cell Signaling Technology), Claudin-1 (#4933; Cell Signaling Technology), and Vimentin (#5741; Cell Signaling Technology). ..

    Expressing:

    Article Title: H3N2 influenza virus infection enhances oncostatin M expression in human nasal epithelium.
    Article Snippet: Tight junctions (TJs) alteration is commonly seen in airway inflammatory diseases.. Oncostatin M (OSM) is an inflammatory mediator associated with chronic rhinosinusitis with nasal polyps (CRSwNP).. We have previously shown that human nasal epithelial cells (hNECs) are highly permissive cells for influenza A virus (IAV).

    Single Cell:

    Article Title: H3N2 influenza virus infection enhances oncostatin M expression in human nasal epithelium.
    Article Snippet: Tight junctions (TJs) alteration is commonly seen in airway inflammatory diseases.. Oncostatin M (OSM) is an inflammatory mediator associated with chronic rhinosinusitis with nasal polyps (CRSwNP).. We have previously shown that human nasal epithelial cells (hNECs) are highly permissive cells for influenza A virus (IAV).

    Staining:

    Article Title: H3N2 influenza virus infection enhances oncostatin M expression in human nasal epithelium.
    Article Snippet: Tight junctions (TJs) alteration is commonly seen in airway inflammatory diseases.. Oncostatin M (OSM) is an inflammatory mediator associated with chronic rhinosinusitis with nasal polyps (CRSwNP).. We have previously shown that human nasal epithelial cells (hNECs) are highly permissive cells for influenza A virus (IAV).



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    (a) Representative bright-field images showing morphological changes in BV2 microglia following <t>recombinant</t> <t>OSM</t> stimulation. Compared with untreated cells, OSM-treated BV2 cells exhibited enlarged soma, shortened processes, and a more amoeboid-like morphology, consistent with microglial activation. (b) CCK8 assay detects the cell viability of each group; (c, d) The representative images and quantitative analysis of protein expression of IL-6, TNF-α, and β-actin detected by Western blot; Data were expressed as the mean±SEM, * P < 0.05, ** P < 0.01, vs. indicated groups n = 3 for each group.
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    ( A ) CellChat analysis of TRL subset interactions with AT2s. ( B ) Heatmap showing the interactions of IFNγ and <t>OSM</t> signaling pathways from TRL subsets to AT2s, analyzed by CellChat. ( C ) Plots showing the expression of Osm and Ifng in young and aged TRL subsets. ( D ) Images of organoids derived from AT2s of young mice co-cultured with TRL subsets from young or aged mice. ( E and F ) Quantification of colony-forming efficiency (CFE) and organoid size. ( G ) Images of organoids derived from AT2s of young mice treated with <t>recombinant</t> OSM or IFNγ. ( H and I ) Quantification of colony-forming efficiency (CFE) and organoid size.
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    Image Search Results


    (a) Representative bright-field images showing morphological changes in BV2 microglia following recombinant OSM stimulation. Compared with untreated cells, OSM-treated BV2 cells exhibited enlarged soma, shortened processes, and a more amoeboid-like morphology, consistent with microglial activation. (b) CCK8 assay detects the cell viability of each group; (c, d) The representative images and quantitative analysis of protein expression of IL-6, TNF-α, and β-actin detected by Western blot; Data were expressed as the mean±SEM, * P < 0.05, ** P < 0.01, vs. indicated groups n = 3 for each group.

    Journal: Frontiers in Neurology

    Article Title: Single-cell RNA sequencing reveals microglial proliferative bias and neuroinflammatory communication reprogramming following traumatic brain injury

    doi: 10.3389/fneur.2026.1789863

    Figure Lengend Snippet: (a) Representative bright-field images showing morphological changes in BV2 microglia following recombinant OSM stimulation. Compared with untreated cells, OSM-treated BV2 cells exhibited enlarged soma, shortened processes, and a more amoeboid-like morphology, consistent with microglial activation. (b) CCK8 assay detects the cell viability of each group; (c, d) The representative images and quantitative analysis of protein expression of IL-6, TNF-α, and β-actin detected by Western blot; Data were expressed as the mean±SEM, * P < 0.05, ** P < 0.01, vs. indicated groups n = 3 for each group.

    Article Snippet: When cultures reached 70%−80% confluence, cells were switched to low serum (1% FBS) for 24 h; followed by stimulation with 1, 5, and 10 ug/ml of LPS (Servicebio, GC205009 ) and 25, 50, and 100 ng/ml of OSM recombinant protein (MedChemExpress, HY-P7274) for 24 h, prior to downstream experiments.

    Techniques: Recombinant, Activation Assay, CCK-8 Assay, Expressing, Western Blot

    ( A ) CellChat analysis of TRL subset interactions with AT2s. ( B ) Heatmap showing the interactions of IFNγ and OSM signaling pathways from TRL subsets to AT2s, analyzed by CellChat. ( C ) Plots showing the expression of Osm and Ifng in young and aged TRL subsets. ( D ) Images of organoids derived from AT2s of young mice co-cultured with TRL subsets from young or aged mice. ( E and F ) Quantification of colony-forming efficiency (CFE) and organoid size. ( G ) Images of organoids derived from AT2s of young mice treated with recombinant OSM or IFNγ. ( H and I ) Quantification of colony-forming efficiency (CFE) and organoid size.

    Journal: bioRxiv

    Article Title: Dysregulated tissue-resident lymphocytes drive senile emphysema by impairing alveolar regeneration

    doi: 10.64898/2026.04.22.720146

    Figure Lengend Snippet: ( A ) CellChat analysis of TRL subset interactions with AT2s. ( B ) Heatmap showing the interactions of IFNγ and OSM signaling pathways from TRL subsets to AT2s, analyzed by CellChat. ( C ) Plots showing the expression of Osm and Ifng in young and aged TRL subsets. ( D ) Images of organoids derived from AT2s of young mice co-cultured with TRL subsets from young or aged mice. ( E and F ) Quantification of colony-forming efficiency (CFE) and organoid size. ( G ) Images of organoids derived from AT2s of young mice treated with recombinant OSM or IFNγ. ( H and I ) Quantification of colony-forming efficiency (CFE) and organoid size.

    Article Snippet: Where applicable, 1 ng/mL recombinant mouse IFNγ (Cat#BE0055-1MG; BioXcell) and 20 ng/mL recombinant mouse OSM (Cat#50112-M08H; SinoBiological) were added to the medium.

    Techniques: Protein-Protein interactions, Expressing, Derivative Assay, Cell Culture, Recombinant